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......v About this guide...vi ROG STRIX X399-E GAMING specifications summary viii Package contents...xii Installation tools and components xiii Chapter 1: Product Introduction 1.1 Motherboard overview 1-1 1.1.1 Before you proceed 1-1 1.1.2 Motherboard layout 1-2 1.1.3 Central Processing...Basic Installation 2.1 Building your PC system 2-1 2.1.1 CPU installation 2-1 2.1.2 CPU heatsink and fan assembly installation 2-3 2.1.3 Motherboard installation 2-4 2.1.4 DIMM installation 2-6 2.1.5 ATX power connection 2-7 2.1.6 SATA device connection 2-8 2.1.7 Front I/O connector 2-9 ...
......v About this guide...vi ROG STRIX X399-E GAMING specifications summary viii Package contents...xii Installation tools and components xiii Chapter 1: Product Introduction 1.1 Motherboard overview 1-1 1.1.1 Before you proceed 1-1 1.1.2 Motherboard layout 1-2 1.1.3 Central Processing...Basic Installation 2.1 Building your PC system 2-1 2.1.1 CPU installation 2-1 2.1.2 CPU heatsink and fan assembly installation 2-3 2.1.3 Motherboard installation 2-4 2.1.4 DIMM installation 2-6 2.1.5 ATX power connection 2-7 2.1.6 SATA device connection 2-8 2.1.7 Front I/O connector 2-9 ...
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... cables are unplugged. • Seek professional assistance before you add a device. • Before connecting or removing signal cables from the motherboard, ensure that all power cables are connected. If possible, disconnect all power cables from connectors, slots, sockets and circuitry. • ...Avoid dust, humidity, and temperature extremes. Operation safety • Before installing the motherboard and adding devices on a stable surface. • If you detect any area where it may become wet. • Place the product...
... cables are unplugged. • Seek professional assistance before you add a device. • Before connecting or removing signal cables from the motherboard, ensure that all power cables are connected. If possible, disconnect all power cables from connectors, slots, sockets and circuitry. • ...Avoid dust, humidity, and temperature extremes. Operation safety • Before installing the motherboard and adding devices on a stable surface. • If you detect any area where it may become wet. • Place the product...
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... the new technology it supports. Chapter 4: RAID Support This chapter describes the RAID configurations. These documents are also provided. 4. vi ASUS website The ASUS website (www.asus.com) provides updated information on the motherboard. 2. Optional documentation Your product package may include optional documentation, such as warranty flyers, that you need when installing and configuring...
... the new technology it supports. Chapter 4: RAID Support This chapter describes the RAID configurations. These documents are also provided. 4. vi ASUS website The ASUS website (www.asus.com) provides updated information on the motherboard. 2. Optional documentation Your product package may include optional documentation, such as warranty flyers, that you need when installing and configuring...
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... Check your motherboard package for the following items. Motherboard Accessories Application DVD Documentation ROG STRIX X399-E GAMING motherboard 1 x I/O Shield 1 x SLI™ HB Bridge(2-way-M) 1 x M.2 Screw Package 1 x M.2 bracket 2 x 2-in-1 SATA 6Gb/s Cables 1 x Thermal sensor cable 1 x Q-Connector kit 1 x ROG cable label 1 x Pack of cable ties 1 x ROG fan label 1 x ROG Strix door hanger 1 x RGB LED extension cable 1 x RGB Addressable LED extension cable 1 x ASUS 2T2R dual...
... Check your motherboard package for the following items. Motherboard Accessories Application DVD Documentation ROG STRIX X399-E GAMING motherboard 1 x I/O Shield 1 x SLI™ HB Bridge(2-way-M) 1 x M.2 Screw Package 1 x M.2 bracket 2 x 2-in-1 SATA 6Gb/s Cables 1 x Thermal sensor cable 1 x Q-Connector kit 1 x ROG cable label 1 x Pack of cable ties 1 x ROG fan label 1 x ROG Strix door hanger 1 x RGB LED extension cable 1 x RGB Addressable LED extension cable 1 x ASUS 2T2R dual...
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Installation tools and components 1 Bag of screws PC chassis Phillips (cross) screwdriver Power supply unit AMD SocketTR4 CPU AMD SocketTR4 compatible CPU Fan DDR4 DIMM SATA hard disk drive SATA optical disc drive (optional) Graphics card M.2 SSD module (optional) The tools and components in the table above are not included in the motherboard package. xiii
Installation tools and components 1 Bag of screws PC chassis Phillips (cross) screwdriver Power supply unit AMD SocketTR4 CPU AMD SocketTR4 compatible CPU Fan DDR4 DIMM SATA hard disk drive SATA optical disc drive (optional) Graphics card M.2 SSD module (optional) The tools and components in the table above are not included in the motherboard package. xiii
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... due to static electricity. • Hold components by the edges to the motherboard, peripherals, or components. ROG STRIX X399-E GAMING 1-1 Chapter 1 Chapter 1: Product Introduction Product Introduction 1 1.1 Motherboard overview 1.1.1 Before you proceed Take note of the following precautions before you install motherboard components or change any motherboard settings. • Unplug the power cord from the wall socket before touching...
... due to static electricity. • Hold components by the edges to the motherboard, peripherals, or components. ROG STRIX X399-E GAMING 1-1 Chapter 1 Chapter 1: Product Introduction Product Introduction 1 1.1 Motherboard overview 1.1.1 Before you proceed Take note of the following precautions before you install motherboard components or change any motherboard settings. • Unplug the power cord from the wall socket before touching...
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Chapter 1 1.1.2 Motherboard layout 20 5 BIOS_FLBK LED_CON M.2(WIFI) DIGI+ U31G1_5-8 LAN_U31G1_34 1 26.9cm(10.6in) 2 3 1 RGB_HEADER2 DIGI+ EPU 45 CPU_OPT CPU_FAN EATX12V_1 EATX12V_2 DIGI+ DRAM CPU VGA...) M.2_2(SOCKET3) U31G1_12 Intel I211-AT SocketTR4 ASM U31G2_EA2 U31G2_EC1 3142 6 AUDIO COV_FAN BIOS Super I/O PCIEX16_1 PCIEX4 DIGI+ EPU STRIX X399-E GAMING PCIEX8_2 ICS ASM 1480 AMD® X399 PCIEX16_3 PCIEX1 Lithium Cell CMOS Power ROG TPU 2280 2260 2242 AURA M.2_1(SOCKET3) U31G2_C1 CHA_FAN1 5 7 ASM 1543 ASM 1562 U.2 U31G1_910 6 8 9 10 11 ...
Chapter 1 1.1.2 Motherboard layout 20 5 BIOS_FLBK LED_CON M.2(WIFI) DIGI+ U31G1_5-8 LAN_U31G1_34 1 26.9cm(10.6in) 2 3 1 RGB_HEADER2 DIGI+ EPU 45 CPU_OPT CPU_FAN EATX12V_1 EATX12V_2 DIGI+ DRAM CPU VGA...) M.2_2(SOCKET3) U31G1_12 Intel I211-AT SocketTR4 ASM U31G2_EA2 U31G2_EC1 3142 6 AUDIO COV_FAN BIOS Super I/O PCIEX16_1 PCIEX4 DIGI+ EPU STRIX X399-E GAMING PCIEX8_2 ICS ASM 1480 AMD® X399 PCIEX16_3 PCIEX1 Lithium Cell CMOS Power ROG TPU 2280 2260 2242 AURA M.2_1(SOCKET3) U31G2_C1 CHA_FAN1 5 7 ASM 1543 ASM 1562 U.2 U31G1_910 6 8 9 10 11 ...
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The CPU fits in only one correct orientation. DO NOT force the CPU into the socket to prevent bending the connectors on the socket and damaging the CPU! Ensure that all power cables are unplugged before installing the CPU. 1-4 Chapter 1: Product Introduction Chapter 1 1.1.3 Central Processing Unit (CPU) The motherboard comes with a SocketTR4 designed for the SocketTR4 socket. Ensure that you use a CPU designed for the AMD Ryzen™ Threadripper™ processors. STRIX X399-E GAMING ROG STRIX X399-E GAMING CPU SocketTR4 The SocketTR4 has a different pinout design.
The CPU fits in only one correct orientation. DO NOT force the CPU into the socket to prevent bending the connectors on the socket and damaging the CPU! Ensure that all power cables are unplugged before installing the CPU. 1-4 Chapter 1: Product Introduction Chapter 1 1.1.3 Central Processing Unit (CPU) The motherboard comes with a SocketTR4 designed for the SocketTR4 socket. Ensure that you use a CPU designed for the AMD Ryzen™ Threadripper™ processors. STRIX X399-E GAMING ROG STRIX X399-E GAMING CPU SocketTR4 The SocketTR4 has a different pinout design.
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STRIX X399-E GAMING ROG STRIX X399-E GAMING 288-pin DDR4 DIMM sockets Recommended memory configurations ROG STRIX X399-E GAMING 1-5 A DDR4 module is notched differently from a DDR, DDR2, or DDR3 module. DO NOT install a DDR, DDR2, or DDR3 memory module to the DDR4 slot. DIMM_D1* DIMM_D2 DIMM_C1* DIMM_C2 DIMM_A2 DIMM_A1* DIMM_B2 DIMM_B1* Chapter 1 1.1.4 System memory The motherboard comes with eight DDR4 (Double Data Rate 4) Dual Inline Memory Modules (DIMM) slots.
STRIX X399-E GAMING ROG STRIX X399-E GAMING 288-pin DDR4 DIMM sockets Recommended memory configurations ROG STRIX X399-E GAMING 1-5 A DDR4 module is notched differently from a DDR, DDR2, or DDR3 module. DO NOT install a DDR, DDR2, or DDR3 memory module to the DDR4 slot. DIMM_D1* DIMM_D2 DIMM_C1* DIMM_C2 DIMM_A2 DIMM_A1* DIMM_B2 DIMM_B1* Chapter 1 1.1.4 System memory The motherboard comes with eight DDR4 (Double Data Rate 4) Dual Inline Memory Modules (DIMM) slots.
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...of accessing information from a memory module. The system maps the total size of the lower-sized channel for single-channel operation. • This motherboard does not support DIMMs made up of 512 Mb (64 MB) chips or less (Memory chip capacity counts in Channel A, Channel B, Channel ...vendor-marked value. • For system stability, use a more efficient memory cooling system to get the correct memory modules. • Visit the ASUS website for overclocking may install varying memory sizes in Megabit, 8 Megabit/Mb = 1 Megabyte/MB). • The default memory operation frequency is ...
...of accessing information from a memory module. The system maps the total size of the lower-sized channel for single-channel operation. • This motherboard does not support DIMMs made up of 512 Mb (64 MB) chips or less (Memory chip capacity counts in Channel A, Channel B, Channel ...vendor-marked value. • For system stability, use a more efficient memory cooling system to get the correct memory modules. • Visit the ASUS website for overclocking may install varying memory sizes in Megabit, 8 Megabit/Mb = 1 Megabyte/MB). • The default memory operation frequency is ...
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Chapter 1 PCIEX16_1 PCIEX4 STRIX X399-E GAMING PCIEX8_2 PCIEX16_3 PCIEX1 PCIEX8_4 Slot No. 1 2 3 4 5 6 Slot Description PCIe 3.0/2.0 x16_1 slot PCIe 2.0 x4 slot PCIe 3.0/2.0 x8_2 slot PCIe 3.0/2.0 x16_3 slot PCIe 2.0 x1 slot PCIe 3.0/2.0 x8_4 slot ROG STRIX X399-E GAMING 1-7 Failure to do so may cause you physical injury and damage motherboard components. 1.1.5 Expansion slots Unplug the power cord before adding or removing expansion cards.
Chapter 1 PCIEX16_1 PCIEX4 STRIX X399-E GAMING PCIEX8_2 PCIEX16_3 PCIEX1 PCIEX8_4 Slot No. 1 2 3 4 5 6 Slot Description PCIe 3.0/2.0 x16_1 slot PCIe 2.0 x4 slot PCIe 3.0/2.0 x8_2 slot PCIe 3.0/2.0 x16_3 slot PCIe 2.0 x1 slot PCIe 3.0/2.0 x8_4 slot ROG STRIX X399-E GAMING 1-7 Failure to do so may cause you physical injury and damage motherboard components. 1.1.5 Expansion slots Unplug the power cord before adding or removing expansion cards.
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Chapter 1 AMD Ryzen™ Threadripper™ Processors VGA Configuration PCI Express 3.0 operating mode Single VGA SLI™/CFX 3-Way SLI™/CFX PCIe x16_1 x16 x16 x16 PCIe x8_2 N/A N/A N/A PCIe x16_3 N/A x16 x16 PCIe x8_4 N/A N/A x8 • We recommend that you provide sufficient power when running CrossFireX™ or SLI™ mode. • Connect chassis fans to the motherboard chassis fan connectors when using multiple graphics cards for better thermal environment. 1-8 Chapter 1: Product Introduction
Chapter 1 AMD Ryzen™ Threadripper™ Processors VGA Configuration PCI Express 3.0 operating mode Single VGA SLI™/CFX 3-Way SLI™/CFX PCIe x16_1 x16 x16 x16 PCIe x8_2 N/A N/A N/A PCIe x16_3 N/A x16 x16 PCIe x8_4 N/A N/A x8 • We recommend that you provide sufficient power when running CrossFireX™ or SLI™ mode. • Connect chassis fans to the motherboard chassis fan connectors when using multiple graphics cards for better thermal environment. 1-8 Chapter 1: Product Introduction
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... the power cable before removing or installing any motherboard component. STRIX X399-E GAMING 3D_MOUNT 3D_MOUNT ROG STRIX X399-E GAMING 3D Mount For more details regarding the installation of your motherboard, please refer to these 3D Mount holes for a personalized motherboard. Power-on button The motherboard comes with a power-on the ASUS website at http://www.asus.com. 1-10 Chapter 1: Product Introduction The button...
... the power cable before removing or installing any motherboard component. STRIX X399-E GAMING 3D_MOUNT 3D_MOUNT ROG STRIX X399-E GAMING 3D Mount For more details regarding the installation of your motherboard, please refer to these 3D Mount holes for a personalized motherboard. Power-on button The motherboard comes with a power-on the ASUS website at http://www.asus.com. 1-10 Chapter 1: Product Introduction The button...
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... on the next page for troubleshooting. STRIX X399-E GAMING ROG STRIX X399-E GAMING Q-Code LED ROG STRIX X399-E GAMING 1-11 Q-Code LED The Q-Code LED design provides you with a 2-digit error code that displays the system status. Q LEDs (CPU, DRAM, VGA, BOOT) Q LEDs check key components (CPU, DRAM, VGA card, and booting devices) in sequence during motherboard booting process. If an error...
... on the next page for troubleshooting. STRIX X399-E GAMING ROG STRIX X399-E GAMING Q-Code LED ROG STRIX X399-E GAMING 1-11 Q-Code LED The Q-Code LED design provides you with a 2-digit error code that displays the system status. Q LEDs (CPU, DRAM, VGA, BOOT) Q LEDs check key components (CPU, DRAM, VGA card, and booting devices) in sequence during motherboard booting process. If an error...
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...-compliant pin definition ROG STRIX X399-E GAMING Front panel audio connector We recommend that supports HD Audio. STRIX X399-E GAMING U31G2_C1 SBU2 SBU1 CC1 VBUS RX1RX1+ GND TX1TX1+ VBUS VBUS TX2+ TX2GND RX2+ RX2GND DD+ CC2 ROG STRIX X399-E GAMING USB 3.1 Gen ...2 front panel connector 1-18 Chapter 1: Product Introduction Connect one end of up to 10 Gbps. The latest USB 3.1 Gen 2 connectivity provides data transfer speeds of the front panel audio I /O module that you connect a high-definition front panel audio module to avail of the motherboard...
...-compliant pin definition ROG STRIX X399-E GAMING Front panel audio connector We recommend that supports HD Audio. STRIX X399-E GAMING U31G2_C1 SBU2 SBU1 CC1 VBUS RX1RX1+ GND TX1TX1+ VBUS VBUS TX2+ TX2GND RX2+ RX2GND DD+ CC2 ROG STRIX X399-E GAMING USB 3.1 Gen ...2 front panel connector 1-18 Chapter 1: Product Introduction Connect one end of up to 10 Gbps. The latest USB 3.1 Gen 2 connectivity provides data transfer speeds of the front panel audio I /O module that you connect a high-definition front panel audio module to avail of the motherboard...
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... chassis. Thermal sensor connector (2-pin T_SENSOR) This connector is for USB 2.0 ports. STRIX X399-E GAMING T_SENSOR PIN 1 SENSOR IN GND ROG STRIX X399-E GAMING Thermal sensor connector 1-20 Chapter 1: Product Introduction 5. Connect the thermistor cable and place the sensor on the device or the motherboard's component to 480 Mb/s connection speed. Connect the USB module cable to any...
... chassis. Thermal sensor connector (2-pin T_SENSOR) This connector is for USB 2.0 ports. STRIX X399-E GAMING T_SENSOR PIN 1 SENSOR IN GND ROG STRIX X399-E GAMING Thermal sensor connector 1-20 Chapter 1: Product Introduction 5. Connect the thermistor cable and place the sensor on the device or the motherboard's component to 480 Mb/s connection speed. Connect the USB module cable to any...
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ROG STRIX X399-E GAMING 1-21 These are not jumpers! STRIX X399-E GAMING A CPU_OPT ...ROG STRIX X399-E GAMING CPU fan connectors GND M.2 PWR M.2 IN M.2 PWM J M.2_FAN • DO NOT forget to connect the fan cables to the AIO_PUMP connector. Do not place jumper caps on water cooling device. • Connect the fan of the connector. Insufficient air flow inside the system may damage the motherboard... 5-pin EXT_FAN; 4-pin CHA_FAN1-3) Connect the fan cables to the fan connectors on the motherboard, ensuring that the CPU fan cable is securely installed to the CPU fan connector. •...
ROG STRIX X399-E GAMING 1-21 These are not jumpers! STRIX X399-E GAMING A CPU_OPT ...ROG STRIX X399-E GAMING CPU fan connectors GND M.2 PWR M.2 IN M.2 PWM J M.2_FAN • DO NOT forget to connect the fan cables to the AIO_PUMP connector. Do not place jumper caps on water cooling device. • Connect the fan of the connector. Insufficient air flow inside the system may damage the motherboard... 5-pin EXT_FAN; 4-pin CHA_FAN1-3) Connect the fan cables to the fan connectors on the motherboard, ensuring that the CPU fan cable is securely installed to the CPU fan connector. •...
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... 1 GND +5 Volts +5 Volts +5 Volts -5 Volts GND GND GND PSON# GND -12 Volts +3 Volts +12V DC +12V DC STRIX X399-E GAMING PIN 1 GND GND ROG STRIX X399-E GAMING ATX power connectors • DO NOT connect the 4-pin power plug only, the motherboard may not boot up if the power is inadequate. • If you use a PSU with more high...
... 1 GND +5 Volts +5 Volts +5 Volts -5 Volts GND GND GND PSON# GND -12 Volts +3 Volts +12V DC +12V DC STRIX X399-E GAMING PIN 1 GND GND ROG STRIX X399-E GAMING ATX power connectors • DO NOT connect the 4-pin power plug only, the motherboard may not boot up if the power is inadequate. • If you use a PSU with more high...
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... and SATA mode vertical M Key design and type 2242 / 2260 / 2280 / 22110 PCIe and SATA storage devices. U.2 connector (U.2) This motherboard comes with a U.2 connector which supports PCIe 3.0 x4 NVM Express storage devices. M.2_2(Socket 3)] These sockets allow you to install M.2 SSD modules. STRIX X399-E GAMING U.2 ROG STRIX X399-E GAMING U.2 connector 1-24 Chapter 1: Product Introduction M.2 sockets [M.2_1(Socket 3); Chapter 1 10.
... and SATA mode vertical M Key design and type 2242 / 2260 / 2280 / 22110 PCIe and SATA storage devices. U.2 connector (U.2) This motherboard comes with a U.2 connector which supports PCIe 3.0 x4 NVM Express storage devices. M.2_2(Socket 3)] These sockets allow you to install M.2 SSD modules. STRIX X399-E GAMING U.2 ROG STRIX X399-E GAMING U.2 connector 1-24 Chapter 1: Product Introduction M.2 sockets [M.2_1(Socket 3); Chapter 1 10.